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- Published: 29 October 2025
Extracellular matrix
Nature Aging (2025)Cite this article
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Yi and colleagues demonstrate that age-induced degradation of extracellular matrix generates elastin-derived fragments that activate the innate and adaptive immune system, which evokes systemic inflammaging.
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References
Frasca, D., Blomberg, B. B. & Paganelli, R. Front. Immunol. 8, 1745 (2017).
Yi, J. et al. Nat. Aging https://doi.org/10.1038/s43587-025-00961-8 (2025).
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Ahadi, S. et al. Nat. Med. 26, 83–90 (2020).
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Cite this article
Jin, S.M., Elisseeff, J.H. Aging as a glitch in the matrix. Nat Aging (2025). https://doi.org/10.1038/s43587-025-01009-7
Published: 29 October 2025
DOI: https://doi.org/10.1038/s43587-025-01009-7
